Green Extraction of Greek Propolis Using Natural Deep Eutectic Solvents (NADES) and Incorporation of the NADES-Extracts in Cosmetic Formulation

In this work, a greener approach for the extraction of Greek propolis using ultrasound-assisted method in combination with Natural Deep Eutectic Solvents (NADES) is presented. Propolis natural material outmost interest as it possesses various biological and pharmacological activities therefore used manufacturing extracts useful to fields, such pharmaceutics, cosmetics etc. Herein, five NADES were task-specifically selected appropriate solvents since they provide important assets final NADES-extracts, comparing conventionally organic solvents. The screening study prepared indicated L-proline/D,L-Lactic acid most effective medium raw due extract’s high total phenolic content well its’ significantly higher antioxidant activity. Then, NADES, was optimized by performing Experimental Design effect time, propolis-to-solvent ratio %NADES NADES-water system. All characterized regarding their activity content. optimum NADES-extract an extract derived conventional hydroethanolic solution further LC/MS/MS analysis. results showed that NADES-extracts composition similar or superior presence valuable phytochemicals apigenin, naringenin A disadvantage usually mentioned literature extractions extracted bioactive compounds cannot be easily separated from order obtain dry extracts. However, drawback can converted asset designed are add value end product as-obtained has been successfully incorporated cosmetic cream formulation. organoleptic characteristics formulation also determined.